Abstract
Allium Sativum L. (ASL) extract is one of the medicinal and aromatic products used in pharmaceutical, food, cosmetic and perfumery industries. The scientific literature bibliography regarding process scale-up simulation and techno-economics of phenolic extract from ASL Microwave-Assisted Extraction (MAE) is seldom reported. This study presented optimization and techno-economics of phenolic recovery from ASL extraction. Box-benken design extraction experiment was conducted at irradiation power (520 W – 1040 W), extraction time (2- 10 min) and solid-liquid ratio (0.4 – 1 g/100 ml). The extraction conditions that optimized experimental extractible yield and Total Phenolic Content (TPC) evaluated in Box-benken desirability of Response Surface Methodology. Bioactive finger printing of the extract was analyzed using High Performance Liquid Chromatograph (HPLC). Aspen Batch Process Developer was used for the process techno-economic analysis; profitability uncertainty was analyzed using Monte-Carlo Simulation (MCS). Optimal extractible yield (28.62%) and TPC (76.8 mgGAE/g dry extract) were obtained at irradiation time 7.62 min, microwave power 826.67 Watt (63.6%) with solid-liquid ratio 0.55g/100 ml. The HPLC fingerprint revealed bentulinic acid, galic acid, chlorogenic acid, ellagic acid and ferulic acid. Cost of Manufacturing (COM) for 5L, 50L and 500L extractors gave US$ 1,480, US$ 220 and US$ 56 respectively. Techno-economic results of 500L extraction capacity with 900 kg/year design gave batch size (0.25 kg), production rate (2 kg/min), cycle time (125 min), discounted net present value (38,133 US$), rate of return (34%) and pay back time (2.94yrs). MCS results show high certainties of achieving base case profitability indices. The study shows that MAE of garlic powder is economically feasible.
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