Abstract
The present work is aimed to improve the antimicrobial property and biocompatibility of Fe3+ and Zn2+ dual substituted HA nanoparticles for orthopedic and dental implants. Fe3+/Zn2+-HA with different Fe3+ concentrations (0.05, 0.075 and 0.1 M) bio-ceramic material is synthesized by microwave irradiation, and its structural, functional and surface properties are studied. X-ray diffraction studies clearly identify no significant distortion to HA lattice by the inclusion of dual minerals, but crystallite size (13.66 nm) and crystallinity (0.32208) were decreased. Photoluminescence measurement of Fe3+/Zn2+-HA bio-ceramics exhibits strong blue emission (454 nm) spectrum under the excitation wavelength of 324 nm, which confirms to act as luminescent bio-imaging agent for the future of biomedicine. Moreover, the antibacterial activities of the pure HA, Fe3+ and Zn2+ substituted HA samples, and dual substituted HA are high enough to hinder bacterial colonization. The bio-ceramic sample does not create any adverse effect on the growth of human lung A549 cells, confirming their applicability in biomedical engineering.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
