Abstract
Novel Schiff bases of 2-(1H-tetrazole-5-yl)acetohydrazide were synthesized by employing microwave assisted green synthesis using substituted aldehydes. The structural characterization of the synthesized compounds was done by elemental, FT-IR, 1H NMR and mass spectrometry. The antimicrobial activity was investigated against Gram-positive and negative bacteria such as Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa. The ADME properties and protein binding studies of the test compounds were computed by using SwissADME and AutoDock software. Among all the compounds, compound HNTAC demonstrated stronger binding affinity (-10.37 kcal/mol) than the control cefazolin (-7.2 kcal/mol) for 4OR7. The excellent results of antimicrobial, molecular docking and ADME (in silico) studies enhanced the potential of the compounds under study as candidates for further research exploration.
Published Version
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