Abstract

A novel, highly efficient, eco-friendly, and quick microwave-assisted synthesis of 2, 4, 5- substituted imidazoles by one-pot cyclo condensation of acenaphthoquinone, aromatic aldehydes, and ammonium acetate was reported under solvent-free conditions using ammonium chloride as a catalyst with excellent yield. The present methodology offers several advantages, such as mild reaction conditions, easy workup, short reaction time, excellent yield, purification of products by the non-chromatographic method, and reproducibility in large-scale synthesis. Compounds were characterized by IR, 1HNMR, 13C NMR spectroscopy and their melting points were compared with the literature reports.

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