Abstract
Microwave-assisted (MWA) multicomponent reactions (MCRs) have successfully emerged as one of the useful tools in the synthesis of biologically relevant heterocycles. These reactions are strategically employed for the generation of a variety of heterocycles along with multiple point diversifications. Over the last few decades classical MCRs such as Ugi, Biginelli, etc. have witnessed enhanced yield and efficiency with microwave assistance. The highlights of MWA-MCRs are high yields, reduced reaction time, selectivity, atom economy and simpler purification techniques, such an approach can accelerate the drug discovery process. The present review focuses on the recent advances in MWA-MCRs and their mechanistic insights over the past decade and shed light on its advantage over the conventional approach.
Highlights
Organic chemists are focussed to develop environment friendly sustainable technologies and procedures using atom-efficient reactions from suitable starting materials to meet the demands of present as well as future generations [1,2,3]
As multicomponent reactions and microwave reactions hold their respective advantage over other synthetic protocols, merging strategy with technology proves to be an asset in organic synthesis
This review aims at bridging the hiatus of the previous reviews with mechanistic insights into the MWAMCRs employed for the synthesis of organic and medicinally significant molecules
Summary
Organic chemists are focussed to develop environment friendly sustainable technologies and procedures using atom-efficient reactions from suitable starting materials to meet the demands of present as well as future generations [1,2,3]. Microwave-assisted (MWA) organic synthesis marked its presence on the scientific map in 1986 with two reports of organic syntheses in the kitchen microwave [13,14] This paved a new direction in synthetic chemistry wherein technology was incorporated to achieve the desired results adroitly. The contemporary organic chemistry procedure involving microwave heating has paved way for the molecular diversity that helps in reducing the time required for the drug discovery process. As multicomponent reactions and microwave reactions hold their respective advantage over other synthetic protocols, merging strategy with technology proves to be an asset in organic synthesis. The review has been classified on the basis of the pharmacophores constructed by adopting the MWA-MCRs strategy
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