Abstract
Cancer growth, invasion and metastasis is strongly dependent on the angiogenic ability. A growing amount of clinicopathological studies confirms that intratumoural microvessel density (MVD) is one of the strongest prognostic variables in human cancer. However, vasculature is also related to the amount of haemoglobin that reaches the tumour, thus oxygenation. Moreover, during chemotherapy, the vessel density strongly defines the drug availability to the tumour. Since euoxic conditions are related to a higher response to radiotherapy (RT) and high drug availability to higher chances for the tumour to respond to chemotherapy, it would be suggested that high microvessel density is a marker of a better response to cytotoxic therapy.KeywordsMicrovessel DensityComplete Response RateThymidine PhosphorylaseDrug AvailabilityThymidine Phosphorylase ExpressionThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call