Abstract
During development, cardiomyocytes (CMs) undergo a hypertrophic growth phase to generate load for the heart to pump sufficient blood. However, in the early stages of pathological hypertrophy, stress-induced signal transduction promotes the addition of new contractile units through poorly understood mechanisms to maintain tensional homeostasis. Microtubules provide mechanical resistance in CMs; however, little is known about their role in maintaining tensional homeostasis in response to development and sarcomeric remodeling.
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