Microstructured drug-delivery systems as solid dispersions using peg 6000 and polysorbate 80 containing hydrochlorothiazide: development, synthesis, and physicochemical and morphological characterization

Abstract

Bioavailability indicates the speed of dissolution and absorption of the drug by its active site, characterization of the potential pharmacological effect, dosage of a medication, and the effectiveness of treatment. Microstructured systems make it possible to increase the efficiency of drug release and absorption processes that have low solubility in physiological media and are extremely important in the area of ​​drug development and new pharmaceutical forms. The drug containing hydrochlorothiazide, distributed by RENAME and widely used for the treatment of arterial hypertension is classified as poorly permeable and poorly soluble, thus having low absorption and bioavailability, which requires administration of high doses to generate side effects. and lack of treatment adherence. The application of a microstructured drug-delivery system in the form of a solid dispersion containing hydrochlorothiazide, a lipophilic drug, dispersed in a solid matrix found by the hydrophilic carriers PEG 6000 (polyethylene glycol) and polysorbate80, given the increased solubility, dissolution profile and consequently the bioavailability of the drug. The system was extended physically-chemically and morphologically utilizing testicles such as scanning electron microscopy (SEM), in addition to thermogravimetry (TGA), differential scanning calorimetry (DSC), and infrared absorption spectroscopy, with satisfactory results in that region. formation of an efficient and innovative drug delivery system.