Abstract
Fabrication of bactericidal yet bioactive and biocompatable coatings is still a challenge. Here we report on novel bioactive, bactericidal, antifouling, and cytocompatible TiO2-based multi-element coatings that are effective against multidrug-resistant pathogenes. Bioactive elements (Ca, P, Si, and B) were added from electrolytes during plasma electrolytic oxidation (PEO), after which the coatings were subjected to ion implantation with Fe and Cu ions. Careful selection and optimization of PEO modes allowed obtaining optimal porosity and desired content of bioactive elements. Doping with B or Si improved the proliferation and differentiation of MC3T3-E1 osteoblastic cell. In addition, these materials exhibited good mineralization ability when exposed to simulated body fluid. B- and Si-containing PEO coatings, decorated with Cu nanoparticles, showed good cytocompatibility, strong antibacterial activity against Escherichia coli and Staphylococcus aureus multidrug-resistant strains and completely prevented S. aureus biofilm formation. The B-doped PEO coating also had a pronounced biocidal effect, which may be associated with the boron dissolution and the formation of boron oxide.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
