Abstract
During development of the pulsed power generators the occurrence of the parasitic elements in the circuit is inevitable, which leads to appearance of overvoltage, overcurrent and waveform distortions. This work is focused on the optimization of the microsecond electroporator to enable handling and damping of the parasitic loads. The optimization is based on a flexible PSPICE model of the electroporator, which is used for the compensation of the parasitic parameters. Based on the modelling results the parameters and the circuit elements for the device are selected. The compliance of the prototype’s experimental and the PSPICE simulated output pulses is analysed. The optimized circuit of the microsecond electroporator is designed. The system supports current handling up to 100 A and capable to generate up to 4 kV square wave pulses. DOI: http://dx.doi.org/10.5755/j01.eee.21.6.13758
Highlights
Electroporation is a biomedical technique, which is applied for the targeted and controlled delivery of drugs and other molecules into the cells by means of increase of the cell membrane permeability [1]–[3].The high voltage generators are required for the high intensity electric field generation, which induces reversible and non-reversible cell permeability increase effects [4]–[6]
In this work we present a flexible microsecond electroporator optimization using PSPICE model of the device, which can be used to estimate the influence of transient processes during pulse generation and allows design and implementation of the compensation circuit for parasitic load handling and damping
In order to determine the influence of the parasitic components and develop a compensation circuit for the microsecond electroporator a PSPICE model has been introduced
Summary
Electroporation is a biomedical technique, which is applied for the targeted and controlled delivery of drugs and other molecules into the cells by means of increase of the cell membrane permeability [1]–[3]. The high voltage generators are required for the high intensity electric field generation, which induces reversible and non-reversible cell permeability increase effects [4]–[6]. As a rule a controlled discharge of a capacitor array through the biological load using a pulse forming switch is applied [7]. When the load is increased and the commutated voltage is in the range of several kilovolts, the influence of the stray inductance and other parasitic circuit components is inevitable [8]. The design and implementation of the compensation circuits for parasitic load handling and damping is required [9]–[10]. Implementation of the compensation circuit without preliminary analysis of the transient
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