Abstract
Biology’s era of “Big Data” is well underway, with plumeting costs of DNA sequencing, gene expression and plicing analyses, and similar technologies bringing us an nprecedented understanding of information flow within he cell. However, these new insights must be combined ith a detailed understanding of the physical processes nderlying these systems. Similarly, rapid advances in our bilities to create and manipulate nano-scale structures ust be matched with abilities to observe these structures nd their interactions. With this knowledge, candidate echnologies in fields as diverse as drug delivery and semionductor design can be properly understood and refined. Developments in light microscopy continue apace. By llowing imaging at sub-wavelength resolutions, superesolution fluorescent microscopy (SR-FM) is gradually ridging the gap between traditional FM and electron icroscopy. While the various techniques have their own imitations in temporal and spatial resolution, or in requireents for extensive image processing, in combination they re continuing to yielding extensive and valuable data on rocesses never previously visualised [1]. In electron microscopy, the Transmission Electron berration-corrected Microscope (TEAM) project have ecently determined the source of their long-term probem pushing resolution past 0.5 A. Based on this, ongoing ork to minimise the effect of thermal noise in their chro-
Published Version
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