Abstract
MicroRNAs (miRNAs), a class of endogenous non-coding RNA about 22 nucleotide long, regulate gene expression at the post-transcription level by inhibiting the translation or inducing the degradation of their target mRNAs in organisms. There are two types of adipose tissues: brown and white. White adipose tissues store energy in the form of triglycerides (TGs), while brown adipose tissues catabolize TGs to generate energy. Brown adipose tissues are of great importance to the research of obesity and related metabolic diseases due to their function of preventing people from obesity. A lot of studies have revealed that miRNAs play crucial roles in regulating brown adipocyte differentiation and are modulated by lots of transcription factors and environmental factors, which form a complex regulatory network maintaining the homeostasis of adipose tissues. In this review, we summarize the latest studies of miRNAs in brown adipocyte differentiation, which might provide new strategies for the treatment of obesity and other related diseases.
Published Version
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