Abstract
The high incidence of breast cancer (BC) is linked to metastasis, facilitated by tumor angiogenesis. MicroRNAs (miRNAs or miRs) are small non-coding RNA molecules that have an essential role in gene expression and are significantly linked to the tumor development and angiogenesis process in different types of cancer, including BC. There’s increasing evidence showed that various miRNAs play a significant role in disease processes; specifically, they are observed and over-expressed in a wide range of diseases linked to the angiogenesis process. However, more studies are required to reach the best findings and identify the link among miRNA expression, angiogenic pathways, and immune response-related genes to find new therapeutic targets. Here, we summarized the recent updates on miRNA signatures and their cellular targets in the development of breast tumor angiogenetic and discussed the strategies associated with miRNA-based therapeutic targets as anti-angiogenic response.
Highlights
Breast cancer (BC) is one of the more prevalent occurring forms of cancer in females and the second most frequently occurring type of cancer worldwide (Siegel et al, 2021), and 90 percent of breast cancer deaths are due to the formation of distant organ metastases (Chaffer and Weinberg, 2011)
We summarized the recent updates on miRNA signatures and their cellular targets in the development of breast tumor angiogenetic and discussed the strategies associated with miRNA-based therapeutic potential as anti-angiogenic response
TET1 poorer prognosis pathways miR-20a promotes aberrant vascular mesh size and excessive VEGFA expression In BC patients, vascular endothelial growth factor (VEGF)-A and HIF-1alpha target proteins correlated negatively with miR-20a/b miR-20b acted as a tumor promoter by targeting PTEN expression miR-21 promotes tumor metastasis and angiogenesis by suppressing the CSF1ETS2 pathway miR-29a stimulates BC cell proliferation and EMT through TET1
Summary
Breast cancer (BC) is one of the more prevalent occurring forms of cancer in females and the second most frequently occurring type of cancer worldwide (Siegel et al, 2021), and 90 percent of breast cancer deaths are due to the formation of distant organ metastases (Chaffer and Weinberg, 2011). Angiogenesis is a multi-step and complex process to form new blood vessels from pre-existing ones It begins with the stimulating, migrating, proliferating, and differentiating endothelial cells in response to signals from the surrounding tissue, such as hypoxia (low oxygen levels) (Bentley and Chakravartula, 2017). The expression of miRNAs, which regulate oncogenes and tumor suppressor genes, is changed in different types of human cancers (Hussen et al, 2021a) These molecules have been termed “oncomiRs.” MiRNAs that are directing the process of angiogenesis are called angiomiRs, as they govern angiogenic processes in pathological and physiological circumstances (Table 1) (Suárez and Sessa, 2009). Another study found that miR-126 controls metastasis and angiogenesis through targeting the proangiogenic genes (IGFBP2, PITPNC1, and c-Mer kinase) (Png et al, 2011) These findings suggest that a single miRNA (miR126) regulates cell survival and angiogenesis, with the possibility to help control vascular function and development. In a mouse xenograft model, miR-497 inhibits tumor development and endothelial cell tube formation
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call