Abstract
MicroRNAs as non-invasive biomarkers of renal disease.
Highlights
With an estimated global prevalence of chronic kidney disease (CKD) of 11–13%, non-invasive biomarkers of renal pathology are desperately required to enhance early diagnosis, guide prognosis and monitor response to treatment [1]
MiRNAs in multiple renal diseases have been explored in renal tissue and biofluids including blood, urine, serum, plasma and perfusate from renal ex vivo perfusion systems
MiRNAs can be readily detected from a limited RNA quantity by quantitative real-time PCR (qRT-PCR), the output from high-throughput sequencing often requires a greater RNA quantity that can often only be reliably obtained from renal tissue
Summary
With an estimated global prevalence of chronic kidney disease (CKD) of 11–13%, non-invasive biomarkers of renal pathology are desperately required to enhance early diagnosis, guide prognosis and monitor response to treatment [1]. MicroRNAs as non-invasive biomarkers of renal disease The ideal biomarker should be non-invasive, stable and sensitive, and should dynamically and reflect disease pathology so as to guide diagnosis, treatment response and prognosis.
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