Abstract
Objective:To investigate the role and clinical significance of the expression of microRNA-98(miRNA-98)and microRNA-143(miRNA-143)in development and progression of nasal and paranasal sinus carcinomas.Method:The expression miRNA-98 and miRNA-143 was detected by Real time PCR metheod in the 53 nasal and paranasal sinus carcinomas and 50 nasal polyp tissues and 20 cases of normal muscosa.The expression of miRNA-98 was analyzed in nasal and paranasal sinus carcinomas with different clinicopathogical parameters.Result:The expression of miRNA-98 in nasal and paranasal sinus carcinomas was obvious higher than that in inflammation of the nasal polyp tissues and normal muscosa,which had statistical significant difference(P<0.05).There was a positive correlation between miRNA-98 expression and TNM staging ,lymph node metastasis;but not pathological grade.The expression of miRNA-143 in nasal and paranasal sinus carcinomas was obvious lower than that in nasal polyp tissues and normal muscosa,which had statistical significant difference(P<0.05).Conculusion:miRNA-98 highly expressed in nasal and paranasal sinus carcinomas,miRNA-143 lowly expressed in nasal and paranasal sinus carcinomas.
Published Version
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