Abstract
Head and neck squamous cell carcinoma (HNSC) is a cancer that develops within the mucous membranes around mouth, nose and throat area. The risk factors for developing this type of cancer are tobacco use and serious alcohol consumption. Altered expression of microRNAs (miRNAs) might become novel molecular biomarkers to identify cancer, metastatic site and even the cancer stage. This study aims to identify how miRNA would contribute to the development on HNSC in a specific population of male since males have a higher tendency to get this cancer than females because of the drinking and smoking habits. This study relies on the expression data obtained from NIH GDC Data Portal using TCGA-Assembler. The data were filtered and differentially expressed genes (DEGs) and miRNAs (DEMs) were determined. Afterwards, correlation test was applied to expression data by using MATLAB. Statistical analyses of expression data identified potential miRNAs targeting cancer genes as well as hsa-mir-31, hsa-mir-193b and hsa-mir-205. Further validation analysis can be conducted using RNAhybrid and examination with alternative miRNA databases.
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