Abstract
To explain the microRNA function in gene network, and let the beginner understand the microRNA characteristics in real-life process, by combining the previous work (Elf and Ehrenberg, Genome Res 13(11):2475, 2003; Lenz et al., Cell 118(1):69–82, 2004; Levine et al., Plos Biol 6(1):e229, 2008; Mitarai et al., Phys Biol 4(3):164–71, 2007; Shimoni et al., Mol Syst Biol 3:138, 2007) and our research papers, we show the negative (positive) regulatory function and the fining-tuning function of microRNA. In some life processes, we focus on the mechanisms and effectiveness of microRNA-mediated regulation in the cell cycle and present the basic methods to analyze the microRNA network. These results presented here would provide a new insight on how gene expression is regulated by miRNAs and further guidance for experiments.
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