Abstract
Chromophobe renal cell carcinoma (chRCC) is the third most common subtype of kidney cancers. In the present study, we identified 58 treatment-naïve primary chRCC patients from The Cancer Genome Atlas dataset and analyzed the genome-wide microRNA (miRNA) expression profiles, with the aim to assess the relationship of miRNA expression with the progression and prognosis of chRCC. Overall, a total of 105 miRNAs were found to be differentially expressed between tumor and the adjacent normal tissues from 22 chRCC patients. In the unpaired condition (58 chRCC vs. 22 normal tissues), 77 (96.3%) samples were distinguished correctly by the signatures. In the progression-related profiles, 27 miRNAs were selected for pathologic T and 9 for lymph node involvement. In the survival analyses, the expression levels of mir-191, mir-19a, mir-210, and mir-425 were significantly associated with both recurrence-free survival (RFS) and overall survival, while mir-210 was proven as an independent prognostic factor in terms of RFS. In summary, miRNAs are expressed differentially in chRCC, and unique expression of miRNAs is associated with the progression and prognosis of chRCC.
Highlights
Indicated that miRNAs could function as tumor suppressors or carcinogenic factors, and alteration in miRNA expression might exert critical functions in the development and progression of human cancers[11,12,13,14]
The diagnostic and prognostic characteristics of miRNAs have been explored in various cancer types[15,16], and the cancer-specific miRNA expression profiles in clear cell RCC (ccRCC) have been identified, which were significantly associated with patient survival[17,18,19]
We stringently designed a step-wise study using the data from The Cancer Genome Atlas (TCGA) project, which provides a collection of clinicopathological data and the genome-wide miRNA expression profiles[22]
Summary
Indicated that miRNAs could function as tumor suppressors or carcinogenic factors, and alteration in miRNA expression might exert critical functions in the development and progression of human cancers[11,12,13,14]. The diagnostic and prognostic characteristics of miRNAs have been explored in various cancer types[15,16], and the cancer-specific miRNA expression profiles in ccRCC have been identified, which were significantly associated with patient survival[17,18,19]. The miRNAs in chRCC remain to be elucidated; and the miRNA expression profiles in chRCC and ccRCC vary greatly, which limited the translational application of the findings about ccRCC in the clinical practice of chRCC20,21. We explored the differential expression profiles of miRNAs in chRCC and corresponding normal kidney tissues, and investigated the association between miRNAs and the progression and prognosis of chRCC, with the hope to identify the miRNA expression signatures that could predict the clinical phenotypes and prognosis in chRCC
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