Abstract
Objective To study the microRNA expression profile of rat myoeardium-derived H9c2 cells in-fected with human adenovirus type 3(Ad3).Methods Confluent and unconfluent H9c2 cells were attacked with Ad3.Six hour later total RNAs were harvested and microRNA expression profiling was analyzed by mi-cmRNA array.Results The expression of 54 microRNAs Was down-regulated and 7 micwRNAs Was up-reg-ulated in COnnuent H9c2 cells compared with that in unconiluent H9c2 cells.The expression of 41 miemR-NAs wag down-regulated and 12 Was up-regulated in unconfluent H9e2 cells infected with Ad3 compared with that in unconiluent H9c2 cells without Ad3 infection.There were 8 microRNAs down-regulated and 62 up-regulated in confluent H9c2 infected with Ad3 compared with that in comquent H9c2 ceils without Ad3 infec-tion.Condusion The microRNA expression profile,correlating with different cell growth states,was siguif-icanfly altered by human adenovirus infection. Key words: Human adenovirus; H9c2 cell; microRNA microarray; Myocarditis
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