Abstract
MicroRNAs (miRNAs) are presently experiencing a renewed height of attention not simplest as diagnostics, however specifically as noticeably promising novel objectives or gear for medical therapy in several different malignant diseases. MicroRNAs have emerged as key publish-transcriptional regulators of gene expression, involved in diverse physiological and pathological approaches. It changed into located that several miRNAs are without delay worried in human cancers, along with lung, breast, mind, liver, colon most cancers and leukemia. Biomarkers have many capacity packages in oncology, together with danger assessment, screening, differential analysis, dedication of analysis, prediction of reaction to treatment, and tracking of progression of disease. In this evaluation, we summarize the present day know-how and ideas concerning the involvement of microRNAs in cancer, which have emerged from the take a look at of cellular tradition and animal model systems, which includes the regulation of key cancer-related pathways, which include mobile cycle control and the DNA damage response. Importantly, microRNA molecules are already getting into the health facility as diagnostic and prognostic biomarkers for patient stratification and also as therapeutic targets and marketers. Keywords: MiRNA, Biomarkers, cancer.
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