MicroRNA and skeletal muscle function: novel potential roles in exercise, diseases, and aging.

John J Mccarthy

doi:10.3389/fphys.2014.00290

Abstract

microRNA and skeletal muscle function: novel potential roles in exercise, diseases, and aging.

Highlights

Throughout the last decade, our understanding of the mechanisms involved in gene regulation has increased enormously, no more so than the role of non-coding RNAs in the regulation of gene expression (Cech and Steitz, 2014)
Zacharewicz and colleagues provide a comprehensive review of studies that have described changes in miRNA expression following exercise, with different muscular disorders and aging (Zacharewicz et al, 2013)
Subsequent studies found that myomiRs expression is altered in muscular dystrophy; myomiR-206 was shown to be dysregulated in both Duchene’s muscular dystrophy and the mdx mouse model, consistent with the finding of Liu and coworkers that miR-206 knockout mouse shows an early onset of the dystrophic phenotype (Liu et al, 2012)

Summary

Introduction

Throughout the last decade, our understanding of the mechanisms involved in gene regulation has increased enormously, no more so than the role of non-coding RNAs (ncRNAs) in the regulation of gene expression (Cech and Steitz, 2014). Zacharewicz and colleagues provide a comprehensive review of studies that have described changes in miRNA expression following exercise, with different muscular disorders and aging (Zacharewicz et al, 2013).

Results

Conclusion