Abstract
Purpose: Osteoarthritis is the most common musculoskeletal condition in the elderly population of the UK and is characterised primarily by the degradation of articular cartilage and remodelling of subchondral bone. microRNAs, short noncoding RNA molecules that act to downregulate a specific set of messenger RNA targets, are an important component of molecular networks involved in the musculoskeletal system and therefore also in the onset of osteoarthritis. miR-324 is a microRNA that is significantly upregulated in human osteoarthritic cartilage samples relative to neck of femur fracture controls and as such we hypothesised that it would play a role in disease.
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