Abstract

Purpose: Osteoarthritis is the most common musculoskeletal condition in the elderly population of the UK and is characterised primarily by the degradation of articular cartilage and remodelling of subchondral bone. Genetics is thought to play a key role in osteoarthritis onset and microRNAs, molecules that act to regulate gene expression by repressing translation of messenger RNA, make up a significant part of this. miR-324 is a microRNA that has previously been demonstrated to be significantly upregulated in human osteoarthritic cartilage samples relative to neck of femur fracture controls.

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