Abstract
Purpose: Osteoarthritis (OA) is a common disease that exhibits various clinical symptoms, like joint disorder, cartilage erosion, synovial inflammation, and pain. Proceed degradation of articular cartilage cause remodeling of cartilage integrity, chondrocyte dysfunction, and molecular mechanisms alteration. However, microRNAs exhibited epigenetically regulation of multiple complex mechanisms still not yet univocally clarified in the pathogenesis of OA development. This study aims to represent miR-128a as being detrimental to articular cartilage integrity.
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