Abstract
Hepatitis C virus (HCV) is a human pathogen that causes a persistent infection in the liver that requires precise control over viral replication to be maintained. Successful HCV replication is promoted by many host factors; of importance to this study is microRNA-122 (miR-122) and Poly-C Binding Protein-2 (PCBP2). The HCV 5’ UTR contains two miR-122 binding sites near the first stem-loop (SLI) and a PCBP2 binding region that overlaps the second miR-122 binding site. PCBP2 also binds to the 3’ UTR and has been shown to circularize the HCV genome.
Full Text
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call