Abstract
Diet is a key factor in determining genomic stability is more important than previously imagined because it impacts on all relevant pathways like exposure to dietary carcinogens, DNA repair, DNA synthesis, epigenetic damage and apoptosis. Recent research focuses into how a single micronutrient deficiency is leading to genomic instability and development of degenerative diseases in various stages of life.The study aimed at finding the nutrigenomic mechanism of how a marginal deficiency of any single micronutrient is interrupting in DNA repairing, methylation and synthesis by taking nutrient-nutrient and nutrient-gene interaction into consideration. It also focuses on how recommended dietary allowance is important in achieving DNA integrity and genome stability to prevent degenerative diseases.Exhaustive review of research papers in genome health nutrigenomicsis involved in this study to explore, assimilate and analyze data to understand the importance of micronutrient in maintaining methylation of CpG sequence and preventing DNA oxidation or uracil misincorporation in DNA to stop disease occurrence in individuals.The study finds a direct link between micronutrient deficiency and increased epigenomic damage, resulting into elevated risk for adverse health outcomes during various stages of life like infertility, tumor development and cancer. The overview study concludes with a vision for a paradigm shift in disease prevention strategy based on diagnosis and micro-nutritional intervention of genome or epigenome damage on an individual basis, i.e. personalized prevention of degenerative diseases in genome health clinic.
Highlights
Fundamental cause of many degenerative diseases and lifestyle disorders like cancer, diabetes, neurological dysfunction, cardio-vascular diseases (CVDs) & Obesity is DNA damage and genomic instability.[1]
Micronutrients by acting as co-factor or substrates for enzyme play an important role in protecting DNA damage, DNA repair, methylation of CpG island and lead to cell apoptosis and formation of cancer which can be explained by the mechanism of nutrient-nutrient or nutrient-gene interaction
DNA damage at the base sequence and chromosome level is a fundamental cause of development and propagation of degenerative diseases and multiple micronutrient deficiency &their interaction with genes is powerfully established as influencing factor for causing DNA damage
Summary
Fundamental cause of many degenerative diseases and lifestyle disorders like cancer, diabetes, neurological dysfunction, cardio-vascular diseases (CVDs) & Obesity is DNA damage and genomic instability.[1]. DNA damage at the base sequence and chromosome level is a fundamental cause of development and propagation of degenerative diseases and multiple micronutrient deficiency &their interaction with genes is powerfully established as influencing factor for causing DNA damage. In this context, to fulfill this deficiency, optimum supplementation of micronutrient is needed in preventing DNA damage and resulting degenerative diseases.‘Nutriome’ is the combination of micronutrients in specific recommended value which has taken into consideration for fulfilling this deficiency in the scope of Nutrigenomics study. RDA of each micronutrient should be revised and optimum dosage should be evaluated in personalized basis to balance the internal micronutrient environment and genome integrity
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