Abstract
AbstractFor tissue engineering applications, accurate prediction of the effective mechanical properties of tissue scaffolds is critical. Open and closed cell modelling, mean-field homogenization theory, and finite element (FE) methods are theories and techniques currently used in conventional homogenization methods to estimate the equivalent mechanical properties of tissue-engineering scaffolds. This study aimed at developing a formulation to link the microscopic structure and macroscopic mechanics of a fibrous electrospun scaffold filled with a hydrogel for use as an epicardial patch for local support of the infarcted heart. The macroscopic elastic modulus of the scaffold was predicted to be 0.287 MPa with the FE method and 0.290 MPa with the closed-cell model for the realistic fibre structure of the scaffold, and 0.108 MPa and 0.540 MPa with mean-field homogenization for randomly oriented and completely aligned fibres. The homogenized constitutive description of the scaffold was implemented for an epicardial patch in a FE model of a human cardiac left ventricle to assess the effects of patching on myocardial mechanics and ventricular function in the presence of an infarct. Epicardial patching was predicted to reduce maximum myocardial stress in the infarcted LV from 19 kPa (no patch) to 9.5 kPa (patch) and to marginally improve the ventricular ejection fraction from 40% (no patch) to 43% (patch). This study demonstrates the feasibility of homogenization techniques to represent complex multiscale structural features in a simplified but meaningful and effective manner.
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