Abstract
Purpose . To investigate the composition and concentration of the polymer solutions on structure and physico-mechanical properties of the electrospun scaffolds. Materials and methods. We prepared electrospun scaffolds from poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), polycaprolactone (PCL), and poly(D,L-lactide) (PLA) in concentrations of 6, 8, and 10 %. We investigated mechanical properties of the scaffolds, fiber diameter, and pore size. Results. Concentration of the polymer solution significantly affected fiber diameter but not pore size. The optimal concentrations of PHBV, PLA, and PCL were 8–10 %. Use of PHBV/PLA composition lowered fiber diameter and pore size whilst PHBV/PCL composition increased elasticity of the scaffolds. Conclusion. Composition and concentration of the polymer solutions significantly affects pore size, structure, and diameter of electrospun scaffolds, that influences physico-mechanical properties of the scaffolds.
Highlights
We investigated mechanical properties of the scaffolds, fiber diameter, and pore size
Сосновый бульвар, 6 Тел. 8 (3842) 64-42-38
Summary
ВЛИЯНИЕ СОСТАВА И КОНЦЕНТРАЦИИ РАСТВОРА БИОДЕГРАДИРУЕМЫХ ПОЛИМЕРОВ И ИХ КОМПОЗИЦИЙ НА СТРУКТУРУ И ФИЗИКО-МЕХАНИЧЕСКИЕ СВОЙСТВА МАТРИЦ, ИЗГОТОВЛЕННЫХ МЕТОДОМ ЭЛЕКТРОСПИННИНГА. Изучить влияние состава и концентрации раствора полимерной композиции на структуру волокон и физико-механических характеристик матриц, получаемых методом электростатического формования. Исследовали механические свойства матриц, диаметр волокон и размер пор. Добавление к ПГБВ ПЛА уменьшает диаметр волокон и размер пор, а включение в полимерную композицию ПЛА приводит к увеличению эластичности матриц. Состав полимерной композиции и концентрация раствора оказывают существенное влияние на размер пор, структуру и диаметр волокон, формируемых в процессе электроспиннинга, что в свою очередь сказывается на физико-механических свойствах получаемых матриц. INFLUENCE OF COMPOSITION AND CONCENTRATION OF BIODEGRADABLE POLYMERS ON STRUCTURE. To investigate the composition and concentration of the polymer solutions on structure and physico-mechanical properties of the electrospun scaffolds
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