Abstract
The production of radiopharmaceuticals for application to positron emission tomography necessitates radionuclides of finite specific activity and chemical purity. Reliable, routine production of the short-lived, biologically useful radionuclides has required careful selection of target system materials. The degenerative effects of high beam currents and use of refrigerated cooling units on metallic cyclotron target windows are of particular interest. Repeated subjection of the metallic windows and target bodies to energetic charged particles induces crystalline lattice imperfections and strain hardening. The reduction in ductility of the foil window appears to correlate with an increase in hardness as evaluated using the Knoop microhardness technique and optical microscopic examination on both aluminum and Havar irradiated cyclotron windows. A summary of our results on the above effects will be presented.
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