Abstract
As the most common neurodegenerative disease, Alzheimer's disease (AD) is troubling countless middle-aged and elderly people. Countless scientists devote themselves to the study of AD in order to help sufferers live happier life. One of the most striking features of AD is the large number of activated microglia around amyloid plaques. This suggests that microglia play an important role in the pathogenesis of AD. But conflicting views have emerged about the specific role of microglia. Some have found that microglia, boosted by proteins such as TREM2 and APOE, can clear plaques in the brain, preventing AD from occurring. Others, however, have found that complement activation mechanisms cause microglia to excessively clear synapses to exacerbate the pathology of AD. This review introduces two opposite opinions about microglias effects in Alzheimer's disease, which is actually about the theory about how TREM2 and microglia mitigate Alzheimer's disease, and why complement and microglia can exacerbate Alzheimer's disease.
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