Microfluidic Valve Arrays for Drug Delivery in Organ-On-Chips.

Abstract

We present in this work an array of microfluidic valves altogether with a corresponding custom control interface. This microfluidic network is an integrated drug delivery system intended for Organ-On-Chip (OOC) applications. Recent research works have achieved high-quality OOC platforms. The latter platforms require an increasing complexity and efficient and flexibile drug delivery systems. As many organs can be integrated in a single chip, a large number of micro-fluidic channels is needed to access various specific locations. Thus, we propose to drive the expected large number of switching valves with an embedded on-chip controller. The presented system includes a control interface of 5n channels using n-line control unit.