Abstract
Single cell analytics and new separation techniques are two examples of the fast growing field of microfluidics. Here, we present two microfluidic devices, containing 3D-confinements, for biotechnological or medical applications. The first device provides new purification methods of minicircle DNA (gene vaccines). We developed a dielectrophoresis based continuous-flow separation of DNA depending on the conformation, i.e. linear or supercoiled (ccc) form. Our second device is used for whole cell biocatalyst studies. We developed a microfluidic device for trapping and cultivation of E. coli. Additionally, we proved that UV spectroscopy can be exploited for label-free detection of cofactors, providing monitoring of cofactor leaching.
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