Abstract
Microcirculatory disturbance produced on normal guinea pig mesentery by soluble IgG complexes was observed by in vivo microscopy for one hour.Soluble IgG complexes dropped onto normal guinea pig mesentery produced acute local vascular reactions which were characterized by plasma exudation, stasis, sticking and emigration of leukocytes and hemorrhage. These changes were recognized only in the venules.Evidences have been presented to show that these changes were chiefly brought about by the plasma exudation from the venules. Analyzing various phases of immunologic vascular reactions, the importance of the flow dynamic changes of microcirculatory region was emphasized.
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