Abstract
Microbubble manipulation by acoustic radiation force may play an important role in future drug delivery systems, because the required bubble manipulations, such as bubble trapping at the desired position and payload release by bubble destruction using a high-intensity ultrasonic wave, are controlled by ultrasonic waves. In this paper, a novel method of microbubble trapping by bubble nonlinear oscillation is proposed. Two ultrasonic waves, which have a harmonic frequency relation, are used in order to generate the force for trapping bubbles. The first wave is a pumping wave, which has a relatively high sound pressure. This wave is used for inducing the nonlinear oscillation of bubbles. The second wave is a control wave, whose frequency is set to be the harmonic frequency of the nonlinear bubble oscillation. The pressure gradient of the control wave in conjunction with the harmonic component of nonlinear oscillation generates the Bjerknes force applied to bubbles. This force forms multiple traps with a narrow separation for bubbles, which flow into the cross area of the two ultrasonic waves.
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