Abstract
Since the discovery of penicillin, microbial metabolites have been extensively investigated for drug discovery purposes. In the last decades, microbial derived compounds have gained increasing attention in different fields from pharmacognosy to industry and agriculture. Microbial metabolites in microbiomes present specific functions and canbe associated with the maintenance of the natural ecosystems. These metabolites may exhibit a broad range of biologicalactivities of greatinterest to human purposes. Samples from either microbial isolated cultures or microbiomes consist of complex mixtures of metabolites and their analysis are not a simple process. Mass spectrometry-based metabolomics encompass a set of analytical methods that have brought several improvements to the microbial natural products field.This analytical tool allows the comprehensively detection of metabolites, and therefore, the access of the chemical profile from thosebiological samples. These analyses generate thousands of mass spectrawhich is challenging to analyse. In this context, bioinformatic metabolomics tools have been successfully employed to accelerate and facilitatethe investigation of specialized microbial metabolites. Herein, we describe metabolomics tools used to provide chemical information for the metabolites, and furthermore, we discuss how they can improve investigation of microbial cultures and interactions.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call