Microbial hydroxylation of 2-cycloalkylbenzoxazoles. Part III. Determination of product enantiomeric excess and cleavage of benzoxazoles

A De Raadt,H Griengl,H Weber,M Kreiner,A Zeiser,N Schoo,I Kopper,P Plachota,G Braunegg,M Petsch

doi:10.1016/0957-4166(96)00032-8

Microbial hydroxylation of 2-cycloalkylbenzoxazoles. Part III. Determination of product enantiomeric excess and cleavage of benzoxazoles

A De Raadt, H Griengl + Show 8 more

https://doi.org/10.1016/0957-4166(96)00032-8

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Journal: Tetrahedron: Asymmetry	Publication Date: Feb 1, 1996
Citations: 22

#Determination Of Enantiomeric Excess #Scope Of Reactions + Show 5 more

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Abstract

Abstract An HPLC-system to measure the e.e. of trans -3-(benz-1,3-oxazol-2-yl)cyclopentan-1-ol 6 , cis -3-(benz-1,3-oxazol-2-yl)cyclopentan-1-ol 38 , 3-(benz-1,3-oxazol-2-yl)cyclopentan-1-one 8 and 2-(benz-1,3-oxazol-2-yl)cyclopentan-1-ol 7 simultaneously in the fermentation mixture of the substrate 2-cyclopentyl-1,3-benzoxazole 5 with Cunninghamella blakesleeana DSM 1906 is presented. The scope and limitations of the benzoxazole cleavage reactions is discussed.

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