Abstract
Among the microbiological transformations of steroids 15 α-hydroxylation of 13 β-ethyl-4-gonene-3,17-dione is an industrially important one [Von H. Hofmeister, K. Annen, H. Laurent, K. Petzoldt, R. Wiechert, Arzneim.-Forsch. 36 (1986) 781], since it results in an intermediate of the synthesis of Gestoden, a widely used contraceptive drug. The aim of our research was to select fungal strains for hydroxylation of 13 β-ethyl-4-gonene-3,17-dione which produce the 15 α-hydroxylated product in a high yield. According to our taxonomical studies, several species of Aspergillus, Fusarium, Mortierella, and Penicillium genera fulfill this requirement. It has been reported that the 15 α-hydroxylating enzyme of Penicillium raistrickii is inducible by various steroidal compounds [S. Irrgang, D. Schlosser, H.-P. Schmauder, Biotechnol. Lett. 14 (1992) 33]. We found that the enzyme of Fusarium nivale (VJ-63 strain) is also advantageously induced by norethisterone, which significantly increased the economic efficiency of this biotransformation process [A. Jekkel, É. Ilkőy, J. Sütő, G. Ambrus, Gy. Horváth, I. Bősinger, I. Pallagi, I. Láng, E. Gyepessy, Hungarian Patent Appl. P-9602249 (1996)].
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