Abstract
BackgroundPsychological co-morbidities in irritable bowel syndrome (IBS) have been widely recognized, whereas less is known regarding the role of gut microbial and host metabolic changes in clinical and psychological symptoms in IBS.ResultsA total of 70 diarrhoea-predominant IBS (IBS-D) patients and 46 healthy controls were enrolled in this study. Stool and urine samples were collected from both groups for 16S rRNA gene sequencing and metabolomic analysis.The results showed that fecal microbiota in IBS-D featured depleted Faecalibacterium (adjusted P = 0.034), Eubacterium rectale group (adjusted P = 0.048), Subdoligranulum (adjusted P = 0.041) and increased Prevotella (adjusted P = 0.041). O-ureido-L-serine, 3,4-dihydroxybenzenesulfonic acid and (R)-2-Hydroxyglutarate demonstrated lower urinary concentrations in IBS-D patients. We further built correlation matrices between gut microbe abundance, differentiated metabolite quantities and clinical parameters. Dialister manifested negative association with IBS severity (r = − 0.285, P = 0.017), anxiety (r = − 0.347, P = 0.003) and depression level (r = − 0.308, P = 0.010). Roseburia was negatively associated with IBS severity (r = − 0.298, P = 0.012). Twenty metabolites correlated with anxiety or depression levels, including 3,4-dihydroxymandelaldehyde with SAS (r = − 0.383, P = 0.001), 1-methylxanthine with SDS (r = − 0.347, P = 0.004) and 1D-chiro-inositol with SAS (r = − 0.336, P = 0.005). In analysis of microbe-metabolite relationship, 3,4-dihydroxymandelaldehyde and 1-methylxanthine were negatively correlated with relative abundance of Clostridiumsensu stricto.ConclusionsOur findings demonstrated altered microbial and metabolomic profiles associated with clinically and psychological symptoms in IBS-D patients, which may provide insights for further investigations.
Highlights
Psychological co-morbidities in irritable bowel syndrome (IBS) have been widely recognized, whereas less is known regarding the role of gut microbial and host metabolic changes in clinical and psychological symptoms in IBS
Irritable bowel syndrome (IBS), a common psychosomatic disorder characterized by abdominal pain, bloating and altered bowel habits, is the most commonly diagnosed gastroenterology disorder which affects over 10% of the population globally and the prevalence varies regionally [1, 2]
irritable bowel syndrome (IBS-D) duration of patients varied from 6 months to 20 years, with an average ± SD duration of 3.97 ± 5.04 years
Summary
Psychological co-morbidities in irritable bowel syndrome (IBS) have been widely recognized, whereas less is known regarding the role of gut microbial and host metabolic changes in clinical and psychological symptoms in IBS. Irritable bowel syndrome (IBS), a common psychosomatic disorder characterized by abdominal pain, bloating and altered bowel habits, is the most commonly diagnosed gastroenterology disorder which affects over 10% of the population globally and the prevalence varies regionally [1, 2]. Psychiatric co-morbidities, including higher level of perceived stress, clinically significant depression and/or anxiety, somatization and altered behavioural pattern, are commonly seen in IBS patients and may either predate or generate the intestinal symptoms [4]. It has been reported that up to 94% of IBS patients demonstrate psychiatric disorders, including somatoform disorders, major depression and anxiety [5]. Existing results are still inconsistent [6, 7]
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