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Abstract
Renieramycin M and jorunnamycin C, two isoquinolinequinone compounds differing only at the C-22 ester side chain, were evaluated for their cytotoxic effects on human colon (HCT116) and breast (MDA-MB-435) cancer cell lines. These two compounds displayed potent cancer cell growth inhibition, their IC50 values reaching nanomolar order. To examine their effects on transcription, we carried out oligonucleotide microarray analysis with focus on the similarities and differences between the two compounds in terms of transcriptional profiles. We found that the down-regulation of PTPRK (protein tyrosine phosphatase receptor type K) can be considered as a biomarker responsive to the cytotoxic effects of this class of antitumor marine natural products.
Highlights
Tetrahydroisoquinolinequinones and their reduced forms have attracted considerable interest over the past 30 years due to their potent biological activities [1]
Renieramycin M and jorunnamycin C were isolated from potassium cyanide pretreated sponge, Xestospongia sp., and nudibranch, Jorunna funebris, respectively
Renieramycin M was more potent than jorunnamycin C against human HCT116 colon and MDA-MB-435 breast cancer cell lines [22]
Summary
Tetrahydroisoquinolinequinones and their reduced forms have attracted considerable interest over the past 30 years due to their potent biological activities [1]. Marine natural products can be subdivided into two categories: (1) renieramycin, cribrostatin, jorumycin, and jorunnamycin and (2) ecteinascidins (Figure 1). Jorumycin, which was discovered in very minute quantities from the mantle and mucus of the Pacific nudibranch Jorunna funebris, possesses growth inhibitory activity against various human cancer cell lines [16]. These three compounds have a relatively unstable carbinolamine group that may decomposed during isolation process, they are available in only minute quantities from natural sources. We reported the isolation of jorunnamycins A-C from the mantles, visceral organs, and egg ribbons of the Thai nudibranch Jorunna funebris, following the same procedure that used potassium cyanide [20]. We used compounds on cellular relationship) studies to the antitumor activity of
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