Abstract
Thrombotic microangiopathies (TMA) are a group of entities that are characterized by microangiopathic haemolytic anaemia, thrombocytopenia and different intensities of organ involvement. Thrombocytopenic thrombotic purpura (TTP), the haemolytic uremic syndrome associated with infection by shiga-toxin producing Esherichia coli (STEC-HUS) and atypical haemolytic uremic syndrome (aHUS) are the most important forms of TMA. Their shared mechanism consists of severe damage to the vascular endothelium which causes thrombotic microangiopathy. It is fundamental to immediately establish a differential diagnosis that makes it possible to commence with support measures and specific treatment for the aetiology of the TMA, as without appropriate treatment these entities are associated with a high level of morbimortality.
Published Version
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