Abstract
Micro-structured arrays on silicon wafers with pyramids of different sizes (base of 2, 3.5 or 5 μm 2) and spacings (4–64 μm; 6–96 μm and 10–160 μm, respectively) were manufactured by optical lithography and coated with a 100 nm gold layer. Some of these micro-structured wafers were further modified through direct self-assembly processes with 11-mercapto-1-undecanol or 1-undecanethiol. Four arrays of pyramidal micro-structures (unmodified silicon, gold, hydrophilic or hydrophobic self-assembled monolayer each were incubated with cell suspensions of Escherichia coli and Staphylococcus aureus under their optimal physiological conditions to allow an attachment of the cells. The live cells on the pyramid fields (differing in pyramid size, spacing and coating) were imaged and counted in replicate trials. Cell viability and adhesion was found to be influenced by a combined effect of the zeta-potential of the surface compared to that of the bacterium and surface topography.
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