Micro-LC–MS/MS: The Future of Bioanalysis

Abstract

BioanalysisVol. 5, No. 11 EditorialMicro-LC–MS/MS: the future of bioanalysisDon W Arnold & Shane R NeedhamDon W Arnold* Author for correspondenceEksigent, part of AB Sciex, 1201 Radio Road, Redwood Shores, CA 94065, USA. Search for more papers by this authorEmail the corresponding author at dwarnold@eksigent.com & Shane R NeedhamAlturas Analytics, Inc. 1324 Alturas Dr. Moscow, ID 83843, USASearch for more papers by this authorPublished Online:6 Jun 2013https://doi.org/10.4155/bio.13.31AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: delay volumemicro-LCmicro-LC–MS/MSUHPLCReferences1 Knox JH. Theoretical aspects of LC with packed and open small-bore columns. J. Chromatogr. Sci.18(9),453–461 (1980).Crossref, CAS, Google Scholar2 Reese CE, Scott RPW. Microbore columns – design, construction, and operation. J. Chromatogr. 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Bioanalysis5(11),1387–1396 (2013).Link, CAS, Google ScholarFiguresReferencesRelatedDetailsCited ByResearch Progress on Quantification Methods of Drug Concentration of Monoclonal AntibodiesCurrent Pharmaceutical Analysis, Vol. 18, No. 7On the potential of micro-flow LC-MS/MS in proteomics18 October 2022 | Expert Review of Proteomics, Vol. 19, No. 3Pharmacokinetic and metabolic analysis of an Alzheimer's disease therapeutic in rat serum via microfluidic CZE–MS4 October 2021 | Biomedical Chromatography, Vol. 36, No. 1Omics in medicinal plantsEvaluation of OptiFlow™-MS/MS for bioanalysis of pharmaceutical drugs and metabolitesJason Barricklow, Joseph Tweed, Christopher L Holliman & Ragu Ramanathan18 December 2019 | Bioanalysis, Vol. 12, No. 1Metaproteomics of the human gut microbiota: Challenges and contributions to other OMICSClinical Mass Spectrometry, Vol. 14Microflow UPLC and high-resolution MS as a sensitive and robust platform for quantitation of intact peptide hormonesZhuo Chen, Yun W Alelyunas, Mark D Wrona, Jonathan R Kehler, Matthew E Szapacs & Christopher A Evans12 July 2019 | Bioanalysis, Vol. 11, No. 13Instrumental and technical evolution over the past decade in bioanalysisRobert MacNeill4 April 2019 | Bioanalysis, Vol. 11, No. 7Qualitative and quantitative characterization of protein biotherapeutics with liquid chromatography mass spectrometry20 April 2016 | Mass Spectrometry Reviews, Vol. 36, No. 6Peptide and Protein Bioanalysis Using Integrated Column-to-Source Technology for High-Flow Nanospray2 June 2017SWATH-MS as a tool for biomarker discovery: From basic research to clinical applications16 February 2017 | PROTEOMICS, Vol. 17, No. 3-4Micro-liquid chromatography mass spectrometry for the analysis of antineoplastic drugs from wipe samples21 September 2016 | Analytical and Bioanalytical Chemistry, Vol. 408, No. 28Advances in LC: bioanalytical method transferPatricia Wright & Adrian Wright5 August 2016 | Bioanalysis, Vol. 8, No. 17Key Mass Spectrometry Techniques Used in Clinical Biomarker Research23 August 2016Method development strategies in bioanalysis28 October 2015Sense and nonsense of miniaturized LC–MS/MS for bioanalysisMartijn Hilhorst, Chad Briscoe & Nico van de Merbel23 December 2014 | Bioanalysis, Vol. 6, No. 24Quantitative bioanalysis by microflow LC–MS to support discovery-based pharmacokinetic studies24 October 2014Applications of low-flow LC–SRM for the analysis of large molecules in pharmaceutical R&DMichael E Lassman & Carmen Fernandez-Metzler26 August 2014 | Bioanalysis, Vol. 6, No. 13Quantitation of human peptides and proteins via MS: review of analytically validated assaysDerek L Chappell, Michael E Lassman, Thomas McAvoy, Mingxiang Lin, Daniel S Spellman, Omar F Laterza26 August 2014 | Bioanalysis, Vol. 6, No. 13 Vol. 5, No. 11 Follow us on social media for the latest updates Metrics Downloaded 528 times History Published online 6 June 2013 Published in print June 2013 Information© Future Science LtdKeywordsdelay volumemicro-LCmicro-LC–MS/MSUHPLCFinancial & competing interests disclosureDW Arnold is a Vice President and Principal Scientist at Eksigent, part of AB SCIEX, a manufacturer of micro-LC–MS/MS systems. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download