Enantiomeric purity of chiral derivatizing reagents for enantioresolution

Abstract

BioanalysisVol. 3, No. 18 EditorialEnantiomeric purity of chiral derivatizing reagents for enantioresolutionRavi BhushanRavi BhushanDepartment of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, India. Search for more papers by this authorEmail the corresponding author at rbushfcy@iitr.ernet.inPublished Online:26 Sep 2011https://doi.org/10.4155/bio.11.211AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: chiral derivatizing reagentsenantiomeric purityenantioresolutionHPLCracemic drugsBibliography1 Bhushan R, Martens J. Amino Acids: Chromatographic Separation and Enantioresolution. HNB Publishing, NY, USA, 32–35 (2010).Google Scholar2 Bhushan R, Brückner H. Use of Marfey’s reagent and analogs for chiral amino acid analysis: assessment and applications to natural products and biological systems. J. Chromatogr. B DOI: 10.1016/j.jchromb.2011.05.058 (2011) (Epub ahead of print).Google Scholar3 Bhushan R, Kumar R. Analysis of multicomponent mixture and enantioresolution of proteinogenic and non-proteinogenic amino acids by reversed-phase high-performance liquid chromatography using chiral variants of Sanger’s reagent. Anal. Bioanal. Chem.394,1697–1705 (2009).Crossref, Medline, CAS, Google Scholar4 Bhushan R, Tanwar S. Synthesis of dinitrophenyl-L-Pro-N-hydroxysuccinimide ester and four new variants of Sanger’s reagent having chiral amines and their application for enantioresolution of mexiletine using reversed-phase high-performance liquid chromatography. J. Chromatogr. A1216,5769–5773 (2009).Crossref, Medline, CAS, Google Scholar5 Bhushan R, Kumar V. Indirect enantioseparation of α-amino acids by reversed-phase liquid chromatography using newly synthesized chiral derivatizing reagents prepared from s-triazine chloride. J. Chromatogr. A1201,35–42 (2008).Crossref, Medline, CAS, Google Scholar6 Bhushan R, Kumar V, Tanwar S. Liquid chromatographic enantioseparation of non-protein α-amino acids after derivatization with Marfey’s reagent and its structural variants. Amino Acids36,571–579 (2009).Crossref, Medline, CAS, Google Scholar7 Bhushan R, Tanwar S. RP-LC resolution of (R,S)-atenolol via diastereomerization with Marfey’s reagent and its structural variants under conventional and microwave heating. Chromatographia68,849–853 (2008).Crossref, CAS, Google Scholar8 Bhushan R, Dixit S. Application of hydrazino dinitrophenyl-amino acids as chiral derivatizing reagents for liquid chromatographic enantioresolution of carbonyl compounds. Chromatographia DOI: 10.1007/s10337–011–2063-x (2011) (Epub ahead of print).Google Scholar9 Bhushan R, Dixit S. Enantioresolution of five β-blockers by reversed-phase high-performance liquid chromatography using fifteen chiral derivatizing reagents having amino acids or their amides as chiral auxiliaries on cyanuric chloride platform. Biomed. Chromatogr. DOI: 10.1002/bmc.1653 (2011) (Epub ahead of print).Google ScholarFiguresReferencesRelatedDetailsCited BySynthesis and Chiral Separation of Some 4-thioflavones9 February 2021 | Journal of Chromatographic Science, Vol. 59, No. 9Derivatization procedures and their analytical performances for HPLC determination in bioanalysis24 November 2020 | Biomedical Chromatography, Vol. 35, No. 1Bioanalysis and enantioseparation of dl-carnitine in human plasma by the derivatization approachVinod Kumar Vashistha & Ravi Bhushan12 October 2015 | Bioanalysis, Vol. 7, No. 19Quantitative analysis of drugs in biological matrices by HPLC hyphenated to fluorescence detectionEmmanuelle Lipka & Claude Vaccher14 April 2015 | Bioanalysis, Vol. 7, No. 6Preparative Enantioseparation of ( RS )-Baclofen: Determination of Molecular Dissymmetry14 February 2015 | Chirality, Vol. 27, No. 4Quantitative liquid chromatography–electrospray ionization-mass spectrometry analysis of amine-containing metabolites derivatized with cyanuric chloride and methylamine isotopologuesJournal of Chromatography A, Vol. 1388Amino acids as chiral auxiliaries in cyanuric chloride-based chiral derivatizing agents for enantioseparation by liquid chromatography18 August 2014 | Biomedical Chromatography, Vol. 28, No. 11Enantioseparation of amino alcohols by reversed-phase high-performance liquid chromatography using cyanuric chloride-based chiral derivatizing reagents having amino acids and their amides as chiral auxiliariesActa Chromatographica, Vol. 26, No. 3Liquid chromatographic enantioseparation of ( RS )-mexiletine and ( RS )-fluoxetine using chiral derivatizing reagents synthesized with ( S )-naproxen moiety25 May 2014 | Biomedical Chromatography, Vol. 28, No. 6Indirect enantioseparation of selenomethionine by reversed-phase high-performance liquid chromatography using a newly synthesized chiral derivatizing reagent based on ( S )-naproxen moiety21 March 2013 | Biomedical Chromatography, Vol. 28, No. 1LC Enantioseparation of 30-Component Diastereomeric Mixture of Amino Acids and Detection of d-Isomers Using New Reagents with Amines as Chiral Auxiliaries in Cyanuric Chloride18 July 2013 | Chromatographia, Vol. 76, No. 17-18LC-MS Bioanalysis of Chiral Compounds30 August 2013Indirect enantioseparation of proteinogenic amino acids using naproxen-based chiral derivatizing reagent and HPLC7 December 2012 | Biomedical Chromatography, Vol. 27, No. 6Application of optically pure amines as chiral auxiliaries to develop trichloro- s -triazine-based new chiral derivatizing reagents for reversed-phase high-performance liquid chromatographic enantioseparation of dl -selenomethionine26 March 2013 | Biomedical Chromatography, Vol. 15 Vol. 3, No. 18 Follow us on social media for the latest updates Metrics Downloaded 175 times History Published online 26 September 2011 Published in print September 2011 Information© Future Science LtdKeywordschiral derivatizing reagentsenantiomeric purityenantioresolutionHPLCracemic drugsFinancial & competing interests disclosureThe author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.No writing assistance was utilized in the production of this manuscript.PDF download