Abstract
From the determination of the Michaelis-Menten kinetic parameters (Vm and Km) of renal tubular secretion of D-(—)-p-n-propylmandelic acid (V) and D-(—)-p-isopropylmandelic acid (VI) in rats, it is shown that these compounds involve the same renal tubular carrier for their secretion but the affinity of V for the carrier is approximately twice that of VI. By considering these parameters as well as the structural variations of V and VI, together with those of other homologs of D-(—)-mandelic acid (I) studied previously, inferences have been drawn regarding the chemical nature around the possible cationic receptor site of the carrier for renal tubular secretion of organic anions in rats. The utilization of the model compounds of a homologous series of I in studying the influence of alkyl groups present in the organic anions on the pharmacokinetic parameters, particularly the volume of distribution, is discussed.
Published Version
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