MICELLIZATION BEHAVIOUR OF CONVENTIONAL (SDS AND DTAB) AND SYNTHESIZED GEMINI SURFACTANT (12-2-12) IN AQUEOUS SOLUTIONS OF METFORMIN HYDROCHLORIDE AT VARYING TEMPERATURES: A COMPARATIVE STUDY

Abstract

The micellar properties of two common surfactants, namely sodiumdodecyl sulphate (SDS) which is of anionic character and dodecyltriamonium bromide (DTAB) of cationic type alongwith 12-2-12 gemini surfactant which was produced in aqueous solutions of 0.001, 0.005 and 0.01 mol∙kg-1 aqueous solutions of metformin hydrochloride (Mfm-HCl) (antidiabetic drug) at 25, 35 and 45 degree Celsius has been analyzed through conductometry. The obtained conductivity data has been used to determine one of the most important characteristic of surfactants known critical micelle concentration (CMC); the concentration above which micelles are formed. The variation in CMC with content of metformin hydrochloride has been compensated in terms of hydrophobic interactions. The drug has been found to diminish the CMC of both types of surfactants (conventional and synthesized). In terms of the hydrophilic/hydrophobic interactions existing in the system, the effect of temperature on the micellization behaviour of these discussed surfactants has also been studied. Moreover, energetics of micellization has also been discussed by using phsedo-phase separation model for all the studied systems in terms of thermodynamic parameters viz. standard enthalpy, free energy, and entropy, of micellization and viewed in terms of different interactions that may exist in the system. The influence on the micro polarity of micellar environment has been discussed by pyrene probe fluorescence technique and used to determine CMC which has been discovered to have a strong resemblance to conductivity studies.