Mối liên quan giữa mức độ sao chép gen KIAA1199 với một số đặc điểm lâm sàng, giải phẫu bệnh của người bệnh ung thư đại trực tràng tại Bệnh viện đa khoa Đức Giang năm 2022-2023

Abstract

Background: Determine the level of KIAA1199 gene copy in FFPE tissue samples of colorectal cancer (CR) patients and evaluate of the relationship between KIAA1199 gene copy level and some clinical and pathological symptoms of CRC patients at Duc Giang General Hospital in year 2022-2023. Methods: A cross-sectional descriptive study on 40 FFPE samples and 40 corresponding medical records of CRC patients diagnosted and treated at Duc Giang General Hospital in year 2022-2023. Result: 26/40 FFPE tissue samples (65.0%) were processed to meet the requirements for RNA extraction quality to evaluate the KIAA1199 gene copy level. Furthermore, 20/26 samples (76.9%) had a higher level of KIAA1199 gene copy in tumor tissue than in normal tissue. There was a statistically significant association between increased KIAA1199 gene copy levels and level of tumor differentiations and types in CR patients (p<0.05); among them, CR patients with neoplasms have increased 11.3 times the KIAA1199 gen copy level higher than CR patients with other types of tumors (p<0.05). However, it was not possible to evaluate the statistically significant relationship between the KIAA1199 gene copy level and some histopathological characteristics such as tumor location, tumor number, histopathological type, level of serosal invasion, lymph node metastasis, and stages classified according to TNM (p>0.05). Conclusion: In this study, the KIAA1199 gene copy levels in tumor tissue increased more strongly than in normal tissue and a statistically significant relationship between the increased KIAA1199 gene copy levels and the tumor differentiations and types in CR patients (p<0.05).