Abstract
Coronaviruses produce both acute and chronic diseases in various animal species. A recent review summarizes the biology and pathogenesis of coronaviruses.1 Of special interest is the chronic demyelinating disease produced by mouse hepatitis virus (MHV) in rodents. This model has been used to study the mechanisms of virus-induced demyelination. Information acquired from such an experimental system may shed light on the pathogenesis of human demyelinating disease.
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