Abstract
Mitsugumin 29 (MG29), a member of the synaptophysin-like family proteins, is a transmembrane protein mainly expressed in the t-tubule membranes of skeletal muscle. Electron microscopy analysis of skeletal muscle derived from mg29-/- mice revealed morphological defects of t-tubules, indicating importance of MG29 in maintenance of muscle structure and function. To determine the function of MG29 in muscle physiology and regeneration, we performed co-immunoprecipitation and found that MG29 can bind to Bin1, another t-tubular protein.
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