Metronidazole-Induced Aseptic Meningitis during Helicobacter pylori Eradication Therapy

Abstract

Letters6 March 2007Metronidazole-Induced Aseptic Meningitis during Helicobacter pylori Eradication TherapySujoy Khan, MBBS, Basil Sharrack, MD, PhD, and W.A.C. Sewell, MBBS, PhDSujoy Khan, MBBSFrom Scunthorpe General Hospital, Scunthorpe, United Kingdom; Lincoln County Hospital, Lincoln, United Kingdom; and University of Lincoln, Brayford Pool, Lincoln, United Kingdom.Search for more papers by this author, Basil Sharrack, MD, PhDFrom Scunthorpe General Hospital, Scunthorpe, United Kingdom; Lincoln County Hospital, Lincoln, United Kingdom; and University of Lincoln, Brayford Pool, Lincoln, United Kingdom.Search for more papers by this author, and W.A.C. Sewell, MBBS, PhDFrom Scunthorpe General Hospital, Scunthorpe, United Kingdom; Lincoln County Hospital, Lincoln, United Kingdom; and University of Lincoln, Brayford Pool, Lincoln, United Kingdom.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-146-5-200703060-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Drugs can cause symptomatic meningitis with cerebrospinal fluid (CSF) abnormalities, such as neutrophilic pleocytosis, and increased CSF protein that mimic infection. Nonsteroidal anti-inflammatory drugs (NSAIDs) and antimicrobials are the most common causes of drug-induced aseptic meningitis.Objective: To report a case of a patient who had 3 episodes of aseptic meningitis during eradication therapy for Helicobacter pylori infection.Case Report: A 42-year-old man was admitted in July 2004, reporting headache, nausea, photophobia, and neck stiffness within 2 hours of taking lansoprazole (30 mg), amoxicillin (1 g), and metronidazole (400 mg) combination therapy. He had been diagnosed with viral meningitis ...