Abstract
Both 2,3,6- and 2,6-methylated derivatives of α and β cyclodextrins were added to the mobile phases in liquid chromatography using an octadecylsilyl stationary phase. The 2,3,6-methyl-substituted derivative of α-cyclodextrin improves the separation of the ortho, meta and para isomers of disubstituted benzenes and also decreases their retention compared with the unmodified α-cyclodextrin. By the addition of 2,3,6-methylated β-cyclodextrin, the three isomers of nitrobenzoic acid can be completely separated, and the separation of trans-nitrocinnamic acid is greatly improved. In contrast, 2,6-dimethylation of both α- and β-cyclodextrins did not bring about such significant improvements in the retention of the solutes investigated.
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